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204 In this process, the prominent feature is the accumulation of senescent and failing T cells

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Methods: We leveraged a dataset comprising 39 features and compared three feature selection methods: ANOVA, recursive feature elimination (RFE), and Lasso regression

When ER stress occurs, accumulated unfolded proteins recruit GRP78 and drive its dissociation from IRE1, PERK, and ATF6

Hits advance to PK/brain-exposure and HED anchoring to inform first-in-human dose-finding, thereby linking mechanism discovery to formulation design with translational checkpoints

Page 80 and 81: GPRC6A is an L-amino acid sensing r Page 82 and 83: MEDI 136 Discovery of novel tricycl Page 84 and 85: Kentaro Takai, kentaro-takai@ds-pha Page 86 and 87: Selectively targeting nicotinic ace Page 88 and 89: Amyotrophic Lateral sclerosis/Parki Page 90 and 91: currently used in the treatment of Page 92 and 93: The binding conformation of the inh Page 94 and 95: completed in 7 and 13 steps, with 2 Page 96 and 97: MEDI 161 Identification of novel Dp Page 98 and 99: Trypanosoma cruzi dihydrofolate red Page 100 and 101: Gerritz 1